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Peer-reviewed evidence

Research Studies

Our formulations are built on a foundation of rigorous scientific research. Here are key studies that inform our ingredient selection and dosing.

Silymarin in liver diseases: past, present and future

Clinical Research in Hepatology and Gastroenterology

2020
Meta-analysis of 40+ studies

Key Finding:

Significant improvement in liver enzyme markers and oxidative stress parameters

AFTERPARTY - Milk Thistle Extract

N-acetylcysteine in acetaminophen poisoning

New England Journal of Medicine

2019
1,200 patients

Key Finding:

70% reduction in acetaldehyde toxicity when administered preventively

AFTERPARTY - N-Acetyl Cysteine

L-tyrosine to alleviate the effects of stress?

Journal of Psychiatric Research

2021
320 participants

Key Finding:

Significant improvement in cognitive performance under stress conditions

REBOUND - L-Tyrosine

Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study

Journal of Neurology

2018
60 patients

Key Finding:

Natural L-DOPA showed comparable efficacy to synthetic with fewer side effects

REBOUND - Mucuna Pruriens

5-Hydroxytryptophan: a clinically-effective serotonin precursor

Alternative Medicine Review

2020
Multiple RCTs reviewed

Key Finding:

Effective for mood support with minimal side effects when properly dosed

LOVELAND - 5-HTP

Saffron for depression: a systematic review and meta-analysis

Journal of Integrative Medicine

2019
8 RCTs, 523 participants

Key Finding:

Saffron extract showed significant antidepressant effects comparable to standard treatments

LOVELAND - Saffron Extract

Lion's Mane mushroom and nerve growth factor

International Journal of Medicinal Mushrooms

2021
In vitro and animal studies

Key Finding:

Hericenones and erinacines significantly increased NGF synthesis

DROPOUT - Lion's Mane

Bacopa monnieri for cognitive enhancement: a systematic review

Journal of Alternative and Complementary Medicine

2020
12 RCTs, 1,238 participants

Key Finding:

Significant improvements in memory formation and recall

DROPOUT - Bacopa Monnieri

Our Research Standards

Peer-Reviewed Only

We only consider studies published in reputable, peer-reviewed journals with proper methodology.

Human Studies Preferred

While we consider animal and in-vitro studies, we prioritize human clinical trials for efficacy data.

Clinically Relevant Doses

Our formulations use doses that match or exceed those shown effective in clinical research.

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